huahana
ʻO ka Tetracaine hydrochloride
Nā kikoʻī huahana
MF: C15H25ClN2O2
MW: 300.82
CAS: 136-47-0
1．Tetracaine hydrochloride he mea hoʻomaʻemaʻe kūloko kūloko e hiki ke ālai i ka hana aʻalolo.Hoʻohana ʻia ia i ka infiltration anesthesia, nerve block anesthesia, epidural anesthesia, a me nā mea ʻē aʻe i hoʻohālikelike ʻia me ka procaine, he mea nui kona hopena anesthesia kūloko, a ua hoʻohana nui ʻia i loko o ke keʻena.Ma o ke aʻo ʻana i nā ala synthesis e loaʻa nei, ʻike ʻia ʻo ka synthesis o ka p-butylamino benzoic acid waena ka hana nui i ka synthesis o ka tetracaine hydrochloride, nona nā hemahema o nā mea waiwai paʻa ʻole a i ʻole nā hua haʻahaʻa.Ua hoʻomaikaʻi ka poʻe ʻepekema i kēia.I ka makahiki 1981, ua manao lakou e synthesize p-butylamino benzoic acid ma ka alkylating p-aminobenzoic acid me 1-Bromobutane.Eia nō naʻe, ma muli o ka hoʻokumu ʻole ʻia o nā huahana o ka dibutylation a me ke ʻano paʻa ʻole o nā mea maka, ʻaʻole kūpono kēia ala no ka hana ʻoihana.
2．Tetracaine hydrochloride hoʻohana no ka mucosal ili anesthesia, conduction anesthesia, epidural anesthesia a me ka subarachnoid anesthesia;Hoʻohana ʻia no ka anesthesia ophthalmic surface, ʻaʻole ia e hoʻopaʻa i nā kīʻaha koko, ʻaʻole e hōʻino i ka epithelium corneal, ʻaʻole hoʻonui i ke kaomi intraocular.
3. Hiki i kēia lāʻau lapaʻau ke hoʻonui i ka hopena nerve block o cisatracurium, a pono e hoʻemi ʻia ke ʻano o ka hopena i ka wā e hui pū ai.Ke hui pū ʻia me ka adrenaline, hiki iā ia ke hoʻopaʻa i nā kīʻaha koko, hoʻemi i ke kahe koko, hoʻolōʻihi i ka lawe ʻana i ka lāʻau, a hoʻolōʻihi i ka lōʻihi o ka hana.Akā ʻaʻole kūpono ka hui ʻana o nā mea ʻelua i nā maʻi me ka maʻi puʻuwai, hypertension, hyperthyroidism, peripheral vascular maʻi a pēlā aku.Hiki i ka Hyaluronidase ke hoʻonui i ka diffusion o kēia lāʻau lapaʻau, hoʻolalelale i ka hoʻomaka ʻana o ka anesthesia, hoʻemi i ka pehu kūloko, a pale i ka hoʻokumu ʻana o ka hematoma.Eia nō naʻe, hiki i ka hyaluronidase ke hoʻokē ʻai i ka absorption o kēia lāʻau, ka hopena i ka piʻi ʻana o ka lāʻau anti chemical Book o kēia lāʻau.ʻO kēia lāʻau lapaʻau he derivative o ka p-aminobenzoic acid (PABA).Hoʻohana nā Sulfonamides i ka hopena antibacterial ma ke kāohi ʻana i ka PABA o ka bacteria.Ke hui pū ʻia kēia lāʻau lapaʻau me ka sulfonamides, e kāohi ʻia ka hopena antibacterial o ka hope, no laila ʻaʻole pono e hui pū ʻia nā mea ʻelua.He ʻakika kēia lāʻau a ʻaʻole pono e hui pū ʻia me ka lāʻau wai alkaline;Hiki i nā lāʻau ʻawaʻawa ke hoʻopilikia i ka waiwai dissociation o ka lāʻau ma muli o ka pH like ʻole, e hopena i ka hana hoʻemi a i ʻole ka lohi o ka manawa hoʻomaka.Hiki i ka hoʻomākaukau ʻana o Iodine ke kumu i ka ua o kēia lāʻau lapaʻau, no laila ʻaʻole hiki ke hoʻohana ʻia ke kahua injection o kēia lāʻau.
Palapala noi
ʻO kēia huahana he ester anesthetic kūloko lōʻihi.ʻO kāna mau hiʻohiʻona: ke komo ikaika i ka mucosa, kūpono no ka anesthesia ma luna, ʻaʻohe hopena ʻino e like me ka vasoconstriction, mydriasis, ʻeha ʻeha ma hope o ka hāʻule ʻana o ka maka.Hoʻohana pinepine ʻia i ka ophthalmology.ʻO ka hopena anesthetic kūloko a me ka ʻona ma kahi o 10 mau manawa ʻoi aku ka nui ma mua o ka procaine.Ma hope o ka hoʻokele ʻana, ʻike mālie ka hopena anesthetic o ka puke kemika (ma kahi o 10 mau minuke), a lohi pū ka metabolism ma hope o ka lawe ʻana.ʻO ka manawa anestheia kūloko a hiki i 3ij, h, -j.pili ana.Hoʻohana nui ʻia ia no ka anesthesia ma luna o ka maka, ka ihu a me ka ʻāʻī mucosa, a ʻaʻole hoʻohana ʻia no ka conduction anesthesia a me ka epidural anesthesia.ʻO ka maʻamau, ʻaʻole ia i hoʻohana ʻia no ka anesthesia infiltration ma muli o kona ʻona kiʻekiʻe.
