huahana
L-Glutathione Kiʻekiʻe i hoʻemi ʻia CAS 70-18-8 no ka mālama ʻili Glutathione
Nā kikoʻī huahana
MF: C10H17N3O6S
MW: 307.32
CAS: 70-18-8
ʻO 1. ʻO Glutathione kahi pūhui tripeptide i hoʻopili ʻia e ka glutamic acid, cysteine a me glycine ma o nā paʻa peptide.ʻO ia ka mea koʻikoʻi haʻahaʻa haʻahaʻa mercaptan i loko o nā ʻenekini mammalian ma lalo o ke koʻikoʻi antioxidant.
ʻO 2.Glutathione (GSH) kahi hui tripeptide i hoʻokumu ʻia e ka condensation o ka glutamic acid, cysteine a me glycine ma o nā paʻa peptide.ʻO kona inoa kemika ʻo γ- Hōʻike ʻia ke kumu hoʻohālike o l-glutamyl-l-cysteyl-glycine ma ka helu 1chemicalbook.Wahi a ke kumu hoʻolālā i ke kiʻi, ʻokoʻa ka GSH mai nā peptides a me nā protein ʻē aʻe.Aia kahi paʻa peptide kūikawā i loko o kāna mole, i hana ʻia me ka glutamic acid γ- Carboxyl (- COOH) a me ka cysteine α- Peptide paʻa i hana ʻia e ka condensation o amino - (- NH2).
3. ʻO ke kaumaha o ka glutathione he 307.33, ʻo ka helu hoʻoheheʻe he 189 ~ 193 ℃ (decomposition), he kala ʻole ke aniani, ʻikea, kolamu slender, a ʻo ka helu isoelectric he 5.93.Hiki ke hoʻoheheʻe ʻia i ka wai, ka waiʻona dilute, ka ammonia wai a me ka methyl formamide, akā hiki ʻole ke hoʻoheheʻe ʻia i ka waiʻona, ether a me ka acetone.ʻO GSH wale nō ka hana physiological i loko o ke kino, a hiki i ka GSSG ke pāʻani i kāna hana physiological koʻikoʻi ma hope o ka hōʻemi ʻana.ʻAʻole maʻalahi ka mālama ʻana o GSH ma lalo o ka hana wai kiʻekiʻe, a hiki ke mālama paʻa no ka manawa lōʻihi wale nō ke hoʻomalu ʻia ka hana wai ma lalo o 0.3.Ua hōʻike nā haʻawina i loko o ka huaʻai ccchemicalbook aqueous solution i loaʻa iā GSH (ph3.3), ma muli o ka hoʻemi ikaika o ka huaora C, ʻaʻole e oxidized ʻo GSH i ka hopena i GSSG, akā ua wikiwiki kona wikiwiki decomposition;ʻAʻole e hoʻololi ʻia ʻo GSSG i loko o ka waiʻona C aqueous solution i GSH, a ʻoi aku ka maikaʻi o kona paʻa ʻana.Eia kekahi, hiki ke hoʻemi ʻia ka GSSG i loko o ka waha i GSH ma ka ʻaoʻao o luna o ka ʻōpū liʻiliʻi, a me ka ʻili o nā pūpū liʻiliʻi epithelial cell γ-GTP (kahi e hoʻoheheʻe ai i ka GSH i loko o ka glutamic acid a me Cys Gly) a hiki i ka dipeptidase ke pāʻani i kāna physiological koʻikoʻi. nā hana.
4.Glutathione nui loa i loko o nā holoholona a me nā mea kanu, a me kona maʻiʻo i loko o ka palaoa hu, palaoa germ a me ka holoholona ate he kiʻekiʻe loa, a hiki i 100 ~ 1000mg/100g;He waiwai nō hoʻi i ke koko kanaka a me nā holoholona, e like me 26chemicalbook ~ 34mg/100g i ke koko kanaka, 58 ~ 73mg/100g i ke koko moa, 10 ~ 15mg/100g i ke koko puaʻa a me 14 ~ 22mg/100g i ke koko ʻīlio.Loaʻa ka GSH i nā mea kanu he nui, ʻuala a me nā kīʻaha.
Palapala noi
ʻO 1.Reduced glutathione he peptide mole liʻiliʻi, aia i loko o nā mea nui i loko o nā mea ola, ʻoi aku hoʻi i loko o nā pūpū ate.Hiki iā ia ke pale i ka membrane o ke akepaʻa, hoʻoikaika i ka hana enzyme ate, a hui pū me nā mea ʻawaʻawa he nui i loko o ka puke kemika e detoxify.He hopena maikaʻi ia i ka ʻeha o ke ake, cirrhosis a me nā maʻi ʻē aʻe i hoʻokumu ʻia e ka lāʻau ʻawaʻawa, ka waiʻona a me nā kumu ʻē aʻe.
2. Loaʻa iā ia nā hana o ka antioxidation, scavenging free radicals, detoxification, hoʻonui i ka immunity, hoʻopaneʻe i ka ʻelemakule, anti-cancer, anti radiation pōʻino a pēlā aku.
3.Biochemical reagents a me antidotes ua hoʻohana nuiʻia no ka makeʻana o nā metala kaumaha, acrylonitrile, fluoride, carbon monoxide a me nā mea hoʻoheheʻe organik.
4.Endogenous antioxidants e pāʻani nui i ka hōʻemi ʻana i nā ʻano oxygen reactive i hana ʻia i ka wā o ka metabolism cell a me ka hanu koke.Hoʻopili ʻo Glutathione-S-transferase i ka hoʻokumu ʻana o ka glutathione sulfide me nā xenobiotics, leukotrienes a me nā molekole ʻē aʻe me nā kikowaena electrophilic.Hoʻokumu pū ʻo Glutathione i nā paʻa disulfide me nā koena cysteine i nā protein.Ma o kēia mau hana, hiki ke loaʻa kahi hopena ʻē aʻe o ka hōʻemi ʻana i ka pono o nā mea anticancer.
